Reoccuring crash [CK2 3.3.0 | GOT 2.1]

I loaded up your save and got a crash the next day, but when I started an observe-mode game from the start, I was able to go 100 years with no crashes. It seems the issue is just with that save. It could be a recurring broken event maybe? In my observe game, I kept the game speed at 3x, so maybe going at the faster speeds causes this. If you end up starting another game, try going at max 3x speed and see if the issue still pops up. I also don't use autosaves; don't know still if that affects anything, but between those two things, I can say I personally haven't had these types of crashes.

If you want to continue with that save, I would say maybe try fast forwarding your game a couple days after the crashes through save-editing (you'll have to keep doing this, so it could become tedious). Some have reported the issue went away eventually for them while for others, it didn't.